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Participants in the FHS underwent standardized anthropometric measurements for height and weight.
Current smoking was defined as self‐report of active smoking within the last year before the examination.
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However, cumulative lifetime risk for SCD has not previously been estimated in any cohort.
Lifetime risk estimation adjusts for competing risks of death, which becomes increasingly important in longer‐term risk estimation given that the risk from other causes of death increases over time.
Blood pressure was the average of 2 separate readings taken by a physician at least 5 minutes apart, as described previously.14 Blood was drawn in EDTA plasma for all cholesterol measurements, as previously described.15 Diabetes mellitus was defined as the use of insulin or hypoglycemic agents or a casual blood glucose ≥11 mmol/L (≥200 mg/d L).
We included 4 risk factors: systolic/diastolic blood pressure, total cholesterol, current smoking status, and diabetes mellitus diagnosis to stratify participants according to the mutually exclusive aggregate risk factor burden strata defined in Table 1.
The importance of establishing risk models composed of important, readily available clinical variables has recently been highlighted.5 The present study used individual participant data from the Framingham Heart Study (FHS) original cohort to estimate the remaining cumulative lifetime risk for SCD in men and women at index ages 45, 55, 65, and 75 years of age.
We report overall cumulative lifetime risks for SCD by sex and also stratify by aggregate risk factor burden at each index age.
Teams compete over a 1,500-2,000 mile course between multiple cities across the country.
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For the present study, we assessed all participants who were free of CVD before their earliest examination between 19 (exams 1–26) and who attended at least 1 examination between the ages of 40 and 94 years.