The leader of the study was 38-year-old psychology professor Philip Zimbardo.

He and his fellow researchers selected 24 applicants and randomly assigned each to be a prisoner or a guard.

Our next steps are to manufacture Mn-Py C3A on a larger scale and conduct additional preclinical safety studies before we can begin testing in human patients." Massachusetts General Hospital. Manganese-based MRI contrast agent may be safer alternative to gadolinium-based agents: Imaging compound developed by Mass.

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General team produces comparable image enhancement to the standard of care with rapid clearance, less likelihood of toxicity." Science Daily. General team produces comparable image enhancement to the standard of care with rapid clearance, less likelihood of toxicity." Science Daily. A specially coated iron oxide nanoparticle could provide an alternative to conventional gadolinium-based contrast agents used for magnetic resonance imaging (MRI). New results in animals highlight a major safety concern regarding a class of magnetic resonance imaging (MRI) contrast agents used in millions of patients each year.

More than 70 people volunteered to take part in the study, to be conducted in a fake prison housed inside Jordan Hall, on Stanford's Main Quad.

Zimbardo encouraged the guards to think of themselves as actual guards in a real prison.

He made clear that prisoners could not be physically harmed, but said the guards should try to create an atmosphere in which the prisoners felt "powerless." The study began on Sunday, August 17, 1971.

The experiment is still a source of controversy and contention—even among those who took part in it.

Here, in their own words, some of the key players in the drama reflect on their roles and how those six days in August changed their lives.

In their report that has been published online in , the team describes experiments showing in a primate model that the manganese-based agent Mn-Py C3A produced contrast enhancement of blood vessels equivalent to that of gadolinium-based agents, which carry significant health risks for some patients.

"About 40 percent of MRI procedures use a contrast agent to produce a signal that can detect cancers, diagnose aneurysms or arterial narrowing, or identify the area of a heart damaged by a heart attack," says Peter Caravan, Ph D, of the Martinos Center for Biomedical Imaging and co-director of the Institute for Innovation in Imaging at MGH, corresponding author of the paper.

Previous studies conducted by the team in mouse models showed that Mn-Py C3A was very resistant to the release of manganese ions; that it provided good enhancement of blood vessels, liver and kidneys; that more than 99 percent was excreted from the body within 24 hours, and that it was eliminated by both the liver and the kidneys, reducing the likelihood of prolonged retention in subjects with poor kidney function.

For the current study, the researchers compared the use of Mn-Py C3A to a commonly used GBCA in a baboon model.

The Stanford Prison Experiment became the subject of numerous books and documentaries, a feature film and the name of at least one punk band.